Via practica 3/2008

RELATIONSHIP OF VISCERAL OBESITY TO CARDIOMETABOLIC RISK FACTORS

Obesity is a progressive disease of unwanted fat accumulation wich has multiple, organspecific pathological consequences, which increased morbidity and decreased quality and life expectancy. Several clinical and epidemilogical studies show that abdominal obesity is much more closely related to cardiometabolic risk factors. The adipose tissue synthethises and secretes a variety of factors: leptin, adiponectin, free fatty acids, interleukin 6, tumor necrosis factor alfa, plasminogen activator inhibitor 1 that many contribut to or worsen of insulin resistance. Insulin resistance has been linked to development of cardiometabolic risk factors such as impaired fasting glucose, impaired glucose tolerance, type 2 diabetes mellitus, atherogenic dyslipidaemia, arterial hypertension, prothrombotic and proinflammatory state. These risk factors are closely related to metabolic syndrome. The aim of this article is to explaine relationship of pathophysiology of visceral obesity to cardiometabolic risk factors.

Keywords: visceral obesity, prediabetes, type 2 diabetes mellitus, atherogenic dyslipidaemia, arterial hypertension, prothrombogenic state, proinflammatory state .