Vaskulárna medicína 3-4/2017
Acquired hemophilia A
Acquired hemophilia A (AHA) is a rare autoimmune disorder that is due to the production of autoantibodies, which inactivate factor VIII. Patients with this disease are at risk of severe bleeding during the presence of the inhibitor. Diagnosis is based on the finding of a low factor VIII level associated with the presence of an autoimmune antibody in the plasma. Management of AHA consists in rapid and accurate diagnosis, control of bleeding and eradication of the inhibitor by immunosuppression. In real clinical practice, AHA is often underdiagnosed and/or misdiagnosed.
Keywords: acquired factor VIII inhibitor, acquired haemophilia A, bleeding, immunosuppression
