Urologie pro praxi 1/2025
Oncological aspects of urolithiasis
Urolithiasis is a complex multifactorial disease resulting from interactions between genetic and environmental factors as well as multiple disease states. The debate about whether urinary calculi induce subsequent malignant changes has continued without a consistent conclusion for several decades. Earlier diagnosis of urolithiasis and its appropriate management can prevent/provide a longer time period for the stones to cause chronic irritation of the local environment or for potentially harmful substances dissolved in the urine to apply their carcinogenic effect. The article clearly deals with current knowledge, opinions and hypotheses in the issue of a possible oncological link between urolithiasis and some urological malignancies. Further studies are needed to clarify the causal relationship and the carcinogenic mechanisms involved. Unequivocal recommendations for clinical practice are still insufficient.
Keywords: urolithiasis, urological tumors, possible common pathophysiology, risk factors, importance for clinical practice.
