Psychiatria pre prax 2/2011

Ziprasidone treatment and metabolic parameters changes

The use of atypical antipsychotics has been associated with abnormalities of glucose and lipide metabolism in patient with various psychotic disorders. The trial was performed according to a prospective, cohort, multicenter, open design in 373 in- and outpatients (57 centers) treated with ziprasidone for broad spectrum of psychotic disorders in flexible dose manner. We have observed statistical significant decrease in fasting serum levels of glucose in patients directly switched from another antipsychotic treatment to ziprasidone. As a result of subgroup analysis we have observed the statistical significant difference in patients previously treated by olanzapine switched to ziprasidone.

Keywords: ziprasidone, glucose metabolism, insuline resistance, metabolic side effects.