Psychiatria pre prax 4/2002

PITFALLS OF POLYPHARMACOTHERAPY

The present paper supplies basic information about the pharmacological risks of polypharmacotherapy in psychiatry. The positive features and the drawbacks of combined therapy are discussed and the possible mechanisms of drug interactions on the pharmacokinetic and pharmacodynamic levels are described.

Keywords: polypharmacotherapy, psychotropic drugs, drug interactions, pharmacokinetics, pharmacodynamics.