Praktické lekárnictvo 4/2017

Adverse drug reactions to the uropoetic system

In the era of modern medicine, patients are exposed to an expanding variety of drugs for diagnostic and therapeutic purposes.Unfortunately, some of these agents cause adverse drug effects linked with systemic toxicity, including impairment of renal function, urinary incontinence, urinary retention, erectile dysfunction, cystitis, etc.While most of these adverse events are clinically insignificant, some drugs may cause unacceptable toxicity that impacts negatively on patient morbidity and mortality.Early recognizing adverse effects is important for administering appropriate drug doses, instituting preventive strategies, and withdrawing the offending agent due to toxicity.This article provides a brief overview of medicines that are associated with impaired renal function, urinary incontinence, urinary retention, erectile dysfunction, cystitis, etc. and summarize risk factors for nephrotoxicity, and for further affections of the uropoetic tract, describe clinical manifestations, and address preventive and treatment strategies of potential drug toxicity.

Keywords: drug induced damage of uropoetic tract, prevention, therapy