Praktické lekárnictvo 1/2015

Interaction of marihuana and hashish components

Herbal drugs – marihuana (Cannabis herba), hashish (Cannabis resina) – originating from different species of the genus Cannabis L., Cannabaceae, and their biologically active compounds are halucinogens. The use of these psychoactive constituents has a low risk factor for dependence. Nevertheless, possessing and cultivating of marihuana for oneself and for distribution is illegal in Slovakia. The endocannabinoid system and its ligands (endocannabinoids) were discovered lately. Observations of the effects of phytocannabinoids of marihuana and hashish on human physiology later inspired medicinal research of cannabinoid receptor agonists and antagonists, as prospective agents to treat diseases, and/or addictions. Literature data leads to concerns on interactions of cannabinoids with medicinal mass products and herbal medicines, or medicinal plants as well.

Keywords: Cannabis, marihuana, hashish, cannabinoid receptors, endocannabinoids, phytocannabinoids, interaction.