Praktické lekárnictvo 1/2023
Gastroretentive dosage forms
The group of gastroretentive delivery systems includes medicines that show the ability to remain in the stomach for a longer period than standard dosage forms. It is a heterogeneous group of products that achieve the gastric retention by various mechanisms. This review provides basic information about these mechanisms, with mention about the physiological aspects which gastroretentive products must deal with. It also contains an overview of marketed gastroretentive products including those registered in the Czech Republic. The last part is a short mention about evaluation specialities.
Keywords: gastroretentive dosage forms, gastroretention, floating systems, sustained release
