Onkológia 2/2012
Prophylactic procedures in women with gene mutations BRCA1 and BRCA2
Breast cancer is the most common oncologic disease in the female population. Besides the sporadic occurrence, it occurs in the familial or hereditary form. Genetic testing for mutation BRCA1 and BRCA2 helps to identify women, who are at increased risk of developing breast and ovarian cancer. Women with the hereditary form of breast cancer occurs in 5–10%. Women with mutations BRCA1 and BRCA2 have to be clasified to intensive dispensaration, and may consider several options for breast cancer prevention, as prophylactic mastectomy, prophylactic salpingo-oophorectomy or chemoprevention.
Keywords: breast cancer, genetic form of breast cancer, BRCA1, BRCA2, contralateral breast cancer, prophylactic mastectomy, prophylactic salpingo-oophorectomy, chemoprevention.
