Onkológia 2/2007
BIOPTIC DIAGNOSIS OF GASTROINTESTINAL STROMAL TUMORS
Gastrointestinal stromal tumors (GIST-s) are the most common mesenchymal tumors of the gastrointestinal tract. They usually show immunohistochemical positivity of CD117 antigen and mutations of the tyrosin kinase receptor – c-KIT or PDGFRA gene. The objective of the paper is to summarize current informations on importance of their biopsy diagnosis, especially in relation to the determination of the GIST´s histologic type, its phenotype and results of the mutational analyses. The importance of all these parameters for the diagnosis and differential diagnosis of GIST´s, its prognosis and therapy is discussed.
Keywords: gastrointestinal stromal tumor, GIST, biopsy diagnosis, prognostic and predictive parameters, tyrosin kinase receptor mutations, KIT, PDGFRA.
