Neurológia pre prax 5/2022

Regular monitoring of cognitive functions in multiple sclerosis

Prevalence of cognitive impairment in multiple sclerosis (MS) is reported to be in range between 35% and 65%. Cognitive impairment in MS has usually a mild form with information processing speed and episodic memory being the most affected cognitive domains. Annual neuropsychological screening of people with MS can provide clinicians with useful data on disease activity and progression; even before the threshold for cognitive impairment is reached. Neuropsychological test batteries BICAMS, MACFIMS or the SDMT test are recommended as the tools of choice for neuropsychological monitoring of MS. The change in cognitive outcomes can be evaluated by Reliable Change Index (RCI) or Standardized Regression Based (SRB) change norm.

Keywords: multiple sclerosis, neuropsychology, cognition, cognitive decline, SDMT, BICAMS, MACFIMS, reliable change index, cognitive screening