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Neurológia pre prax 3/2024
New‑onset refractory status epilepticus
New-onset refraktory status epilepticus (NORSE) is a rare severe condition with possible fatal consequences. Etiology of the syndrome often remains unclear. The term NORSE describes the clinical condition according to patient’s symptoms and history but has no connection with a specific etiology. Achievement of the control of seizures is our main priority in management of every status epilepticus (SE), however finding the etiology of SE has both therapeutic and prognostic implications. Aim of this article is to suggest diagnostic and therapeutic processes based on the considered/confirmed underlying cause of NORSE.
Keywords: new‑onset refractory status epilepticus, cryptogenic NORSE, autoimmune encephalitis, corticosteroids, immunotherapy, ketogenic diet
