Neurológia pre prax 1/2022
Neuropsychiatric comorbidities in patients with DMD
Duchenne/Becker muscular dystrophy, caused by mutations in dystrophin gene,is one of the most frequent muscular dystrophies. Symptoms of DMD include typical movement problems, cardiomyopathy and respiratory failure most often occur in the third decade. In many patients we can find not only movement problems but also neuropsychiatric disorders, esp. autism spectrum disorders, attentiondeficit hyperactivity disorder and obsessive-compulsive disorder. Their incidence is higher than in other population. Probabaly it due to lack of dystrophin in neurons.
Keywords: Duchenne/Becker muscular dystrophy, autism spectrum disorders, attention-deficit hyperactivity disorder (ADHD), obsessivecompulsive disorder (OCD)
