Dermatológia pre prax 4/2017

Paracetamol induced Stevens-Johnson syndrome and toxic epidermal necrolysis overlap syndrome

Stevens–Johnson syndrome and toxic epidermal necrolysis are severe and potentially life-threatening skin conditions caused most frequently by a hypersensitive reaction to medication. Paracetamol, which is the most frequently used pharmaceutical mean for fever and aches, appeared to be a relatively safe medication in a clinical practice. However, there have been several cases of severe post-medical reactions described in the literature. In this article, we present a case report of a patient with Stevens–Johnson syndrome and toxic epidermal necrolysis overlap syndrome following paracetamol use.

Keywords: Stevens-Johnson syndrome, toxic epidermal necrolysis, overlap syndrom, paracetamol.