Dermatológia pre prax 3/2010

The more common recurrent clinical manifestations of Herpesvirus Infection in Man, prevention and therapy

Herpesviruses which affect man occur ubiquitously in all populations throughout the world. It is a characteristic feature of herpesvirus that they generally remain in a latent form after clearance of the primary infection. The overall majority of clinical problems are related to activated latent infections, eg., recurrent lesions of herpes simplex labialis or herpes genitalis and in particular herpesvirus infections and reactivation in immunodeficient individuals. The review concerns the more common recurrent clinical manifestations of herpesvirus simplex infection (HSV 1, 2) in man and a new approaches to the prevention and therapy.

Keywords: herpes simplex virus type 1 and 2, herpes genitalis, herpes labialis, short-course therapy, episodic therapy, suppressive therapy, immunomodulation, vaccination, prevention