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Dermatológia pre prax 3/2008

URTICARIAS INDUCED BY NONIMMUNOLOGICAL MECHANISMS

Urticarias induced by nonimmunological mechanisms (intolerance, nonallergic hypersensitivity) display either acutely intermittent or chronically recurrent course. The pathogenesis involves the effect of vasoactive biogenic amines, histamine liberators, or a genetic disorder of arachidonic acid metabolism. The aetiology primarily includes food additives (preservatives and food colours), acetylsalicylic acid, and nonsteroidal anti-inflammatory drugs. The article provides an overview of the aetiopathogenetic factors, clinical picture, diagnostic procedures, and treatment.

Keywords: intolerance urticarias, nonallergic hypersensitivity, aetiopathogenesis, clinical picture, investigation, treatment.

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