Ambulantná terapia 1/2008

CLINICALY ISOLATED SYNDROME AND SCLEROSIS MULTIPLEX

Multiple Sclerosis (MS) is a chronic inflammatory disorder of the central nervous system characterised by destruction of the myelin sheaths, gliosis and varying degrees of axonal loss resulting in progressive neurological dysfunction. The management of MS has improved dramatically in the last years, with the introduction of a number of disease-moddifying therapies. At present time, worldvise there are accepted the concept of the early immunomodulatory treatment of MS by interferons beta – iniciated after the first demyelinatig event / clinicaly isolated syndrome (CIS) with high risk to conversion to clinically definitive MS. In this work there are presented the most frequent types of CIS, typical for MS and the possibilities of their differential diagnosis.

Keywords: sclerosis multiplex, clinically isolated syndrome, early immunomodulatory treatment