Via practica 3/2010

Significance of combined hypolipidemic therapy for patients with metabolic syndrome

Metabolic syndrome represents a complex of metabolic disorders of serious nature in which lipid disorders are among significant risk factors for developing cardiovascular disease with high morbidity and mortality. Treatment of dyslipidemia with statins or fibrates is among the most widely used therapies. Statin-fibrate combination therapy has been shown to not have an increased risk of adverse effects and to be pharmacologically complementary. However, not even a positive, laboratory-based, therapeutic effect can eliminate the risk of developing a serious cardiovascular disease completely. Diabetic/metabolic dyslipidemia is more susceptible to combination therapy than other types of lipid metabolism disorders. When indicated and administered properly, statin-fibrate combination therapy currently represents a significant treatment option of dyslipidemia reducing a high cardiovascular risk.

Keywords: dyslipidemia, metabolic syndrome, cardiovascular risk, fibrates, statin-fibrate combination therapy