Via practica S4/2007

METABOLIC SYNDROME, CARDIOVASCULAR AND METABOLIC RISK

Metabolic syndrome (MS) is defined as cluster of independent risk factors of type 2 diabetes mellitus and coronary heart disease, including impaired fasting glucose and impaired glucose tolerance, as well as central obesity, dyslipidaemia with typical increasing of triglyceride levels and decreasing of high density lipoprotein levels and arterial hypertension. Insulin resistance together with compensatory hyperinsulinaemia are considered to be primary etiopathogenetic factors of MS, but not mechanism explaining all associated abnormalities. In these times there are different recommendations for diagnostic criteria of MS according to WHO (1999), NCEP – ATPIII (2001), ACE/AACE (2003) and IDF (2005) and new risk factors of its cardiovascular and metabolic complications are searched.

Keywords: metabolic syndrome, insulin resistance, diabetes mellitus type 2, cardiovascular risk.