Vaskulárna medicína 3/2010

Warfarin, food and dietary supplements

Anticoagulation treatment with warfarin and other dicoumarol derivates shows significant interindividual and also intraindividual variation. The effect and doses depend not only on inherited disposition in each individual but also on a range of acquired conditions. Among the acquired factors, besides clinical status, food composition accompanied by medicaments and dietary supplements are very important. In nutrition, content of vitamin K plays an important role. According the latest recommendations, its acquisition should be as stable as possible. It is also simultaneously necessary to avoid a range of dietary supplements because they could be affecting the possibility of bleeding complications without showing on laboratory test results.

Keywords: warfarin, vitamin K, food, dietary supplements