Vaskulárna medicína 1/2019

Edoxaban – metabolism, pharmacological properties and drug interactions

Long term oral anticoagulation is indicated to prevent stroke in patients with atrial fibrillation (AF) and for treatment of venous tromboembolism (VTE). Vitamin K-dependent oral agent (Warfarin) has numerous drug interactions that can either increase the risk of adverse events or decrease the anticoagulant effect of warfarin. Edoxaban is a novel oral anticoagulans, directly inhibiting factor Xa that is largely used for anticoagulation in patients with AF and in patients with VTE because of his pharmacological properties, such as consistent and predictable anticoagulation, rapid onset of action, short half-time, relatively high bioavailability, a good safety profile, and small number of clinical relevant drug interactions. In this article, we review the pharmacological properties of edoxaban, its metabolism, and possible drug interactions.

Keywords: edoxaban, direct oral anticoagulants, drug interactions