Urologie pro praxi 4/2024

New approaches in the treatment of testicular cancer

Testicular germ cell tumors represent a significant challenge in the field of oncology, despite their relatively low incidence. This article focuses on current approaches in their treatment, emphasizing the optimization of care and minimizing the risk of relapse and treatment toxicity. Standard procedures such as orchiectomy, chemotherapy, radiotherapy, and lymphadenectomy are discussed. Special attention is given to the role of new biomarkers, such as miR-371a-3p, which improve the accuracy of diagnosis and treatment monitoring. The article also reflects current trends in therapy de-escalation and research of new targeted therapeutic approaches, including currently studied substances and drug combinations. There is a need for a personalized approach in the treatment of these tumors allowing better outcomes while reducing side effects of the therapy.

Keywords: testicular cancer, orchiectomy, chemotherapy, radiotherapy.