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Urologie pro praxi 3/2019
Genetic impact on spermatogenesis
The cause of male infertility is frequently genetic. The genetic cause may be the chromosome abnormality or the mutation of a gene important for the spermatogenesis or the sperm function. The abnormality could disturb the sperm amount, their morphology, motility or the ability to penetrate the oocyte envelopes, fuse with the oocyte and activate them. Genetic error can also stop the early embryo development. The error affecting male fertility is possibly connected with the occurrence of congenital defects in descendants and therefore genetic examination of the man with fertility disturbance is important.
Keywords: sperm, infertility, genetic cause.
