Psychiatria pre prax 4/2007

WHY THE PATIENTS REFUSE ANTIPSYCHOTICS?

Schizophrenia is a serious disorder. There is necessary long-term antipsychotics´ medication in the treatment of schizophrenia. Compliance in the treatment is low. The presence of adverse events is one from the important reason of early discontinuation of antipsychotics, especially adverse events with unpleasant subjective experience. We would like to describe the importance of subjective reaction to antipsychotics – dysphoria and its importance in compliance and the course of this disorder.

Keywords: dysphoria, subjective experience, antipsychotics, D2 occupance, schizophrenia.