Psychiatria pre prax 2–3/2010

The less common therapeutic approaches in the treatment of mania

The less common therapeutic approaches in the treatment of mania are usually mentioned in the international and national guidelines as second or third line treatment. In this review only in Czech Republic available drugs are mentioned in more details. They include undoubtedly new atypical antipsychotic and some their new formulations (paliperidone and quetiapine extended-release, long-acting injection of risperidone) and atypical antipsychotic used for a long time without controlled trials in this indication (amisulpride, clozapine). Further, some drugs, which are cited in the available literature but practically not used in our country are included (phenytoin, verapamil, nifedipine, tamoxifene, allopurinol).

Keywords: antimanic drugs, paliperidone ER, quetiapine ER, risperidone long-acting injection, amisulpride, clozapine, phenytoin, tamoxifene, allopurinol.