Psychiatria pre prax 4/2017

Treatment of farmacoresistant depression in polymorbid patient

Case report presents the treatment of patients with type 2 diabetes who suffered from depression and whose psychological state after several years of unsuccessful treatment significantly improved with a combination of agomelatine and venlafaxine. Thanks to this medication the patient was improved in both psychological state and metabolic state - significantly decreased body weight and glycated hemoglobin, which is for treatment of diabetes desirable. Case report shows the importance to treat patients for sufficiently long period (if treatment well tolerated) untill the therapeutical effect land. Furthermore, agomelatine appeared to be suitable for the treatment of depression in polymorbid patients with drug combination, thanks to its profile of drug interactions and low rate of side effects.

Keywords: diabetes mellitus, depression, antidepressant, venlafaxine, agomelatine