Psychiatria pre prax 6/2006

DOSING OF ANTIPSYCHOTICS IN THE TREATMENT OF SCHIZOPHRENIA

Schizophrenia is a serious disorder with the beginning especially in the adolescent and early adult ages. There is a high percentage of chronic course in this disorder. Long-term antipsychotic medication is necessary in the treatment, first in the treatment of acute state and then in the profylaxis of relapses. During the treatment of antipsychotics is the risk of development of adverse events, which has an influence on acute and long-term compliance. One of the possibilities of prevention of development of adverse events is an adequate dosage of this medication. The survey of factors, which are necessary to pay attention for choosing of the dose of antipsychotics, is presented in this article.

Keywords: antipsychotics, schizophrenia, dosage, D2 occupancy, compliance, adverse events.