Praktické lekárnictvo 4/2011

Contribution to questions of pharmacological treatment in the elderly

Pharmacotherapy in the elderly is complicated by multifactorial issues, including age-related physiologic changes, the presence of multiple chronic disease states, functional changes in mental and physical abilities, and decrease of patienťs ability to comply with recommended therapy. Adverse drug reactions and interactions are more common than in the general l population. Geriatric clinical syndromes can be induced or exacerbated by prescribed and OTC pharmaceuticals. Pharmacodynamic and pharmacokinetic changes may alter response to a given medication resulting in increased risc of adverse reactions. Pharmacotherapy in elderly requires specific approach and awareness in indicating medication to senior patiens.

Keywords: pharmacotherapy in the elderly, polymorbidity, polypraharmacy, pharmacokinetics, pharmacodynamics, adverse reactions, compliance.