Praktické lekárnictvo 4/2011

New medicinal substances in extemporaneous prescription, part 10 – lidocaine and lidocaine hydrochloride

The article presents the lidocaine base and its hydrochloride salt as a well-known and long term used local anesthetic agent, shows the differences in their properties and uses, thus the occurrence of various dosage forms. The article presents the possibilities of preparation of dosage forms containing lidocaine/lidocaine hydrochloride, because both substances are relatively newly available for magistral preparations in pharmacies. Examples of formulas suitable for extemporaneous preparations containing lidocaine such as lidocaine emulgel and polyethylenglycol ointment are also presented.

Keywords: lidocaine emulgel, binary eutectic mixture, lidocaine-polyethyleneglycol ointment, magistral preparation.