Pediatria pre prax 1/2017

Development of treatment of nephrotic syndrome in children

The term „nephrotic syndrome“ designates a combination of clinical and laboratory features that occur in numerous pathological lesions of the glomeruli. The first medical reports of nephrotic syndrome in infants and children and its treatment with plant extracts and other remedies dating back to ancient times. It took a long time while effective treatments were found. They appeared to the 50-ies of the last century thanks to the discovery of steroids, antibiotics, diuretics and also various immunomodulating agents. Despite this progress, there are still substantial gaps in our understanding of the etiology of nephrotic syndrome and more effective treatments are expected, particularly for the frequently relapsing and/or treatment resistant forms of the syndrome in children.

Keywords: nephrotic syndrome, diagnosis, treatment, children, history