Pediatria pre prax 2/2005

CURRENT VIEW ON THE PATHOGENESIS AND MANAGEMENT OF ATOPIC DERMATITIS

A precise understanding of the genetic, metabolic and immunologic mechanisms is crucial for development of effective treatment strategies for atopic dermatitis. Various studies indicate that it has a multifactorial cause, with activation of complex immunologic and inflammatory pathways. Treatment of atopic dermatitis requires a comprehensive approach that includes evaluation of potential triggers and education of the patient and family regarding proper avoidance measures. Hydration of the skin and maintenance of an intact skin barrier remain integral to proper management. Although topical corticosteroids have been a mainstay of anti-inflammatory therapy, the newer topical calcineurin inhibitors offer advantages for treatment of this chronic, relapsing disease.

Keywords: atopic dermatitis, etiopathogenesis, therapy.