Pediatria pre prax 4/2007

ACTUAL TRENDS IN PREVENTION AND TREATMENT OF TYPE 1 DIABETES MELLITUS

Type 1. diabetes mellitus results from an autoimmune destruction of insulin producing pancreatic beta cells. Long interval between the start of the autoimmune process to the real manifestation and the possibility to identify subjects in high risk of the development of the disease based on their genetics, presence of diabetes related autoantibodies and the status of the metabolism of glucose make this disease very attractive target of the prevention on all of its three stages. This article lists in detail important projects of T1DM prevention carried on recently or currently under research and possibilities of replacement or renewal of the insulin self-production, i. e. the causal treatment including the islet transplantations, the stem cell and the gene therapy.

Keywords: DM 1, prediction, prevention, causal therapy.