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Onkológia 4/2008
ADVANCES IN NEUROBLASTOMA DIAGNOSTICS AND TREATMENT
Neuroblastoma is the most common extracranial solid tumor of a childhood. Neuroblastoma is well known for its variability in clinical behavioral and distinct biological features. In a history of pediatric oncology it is a first disease, where the biological marker (NMYC amplification) was used for a prospective therapeutical randomisation. Current research is focused on detection of a new biological prognostic markers in neuroblastoma and implementation af a new therapeutical approaches into a clinical practise (eg. antiangiogenic therapies, metronomic chemotherapy, biotherapy, immunotherapy).
Keywords: neuroblastoma, pediatric oncology, new terapie, antiangiogenic therapy, metronomic chemotherapy, COMBAT
