Onkológia 3/2017

Biologic therapy in older patients

With the aging of the population increase the number of older patients with cancer . Treatment of older people is difficult. We are now in the era of personalized biological antitumor treatment, but the data supporting targeted therapy in elderly patients with cancer are not satisfactory. Inadequate representation of elderly patients in registration trials is a major problem. Often older patients enrolled to large clinical trials are not „true“ representative of elderly oncology population, therefore the efficacy and safety data from these trials can not be generalized to whole older oncology population. Majority of targeted therapies are recommended for use in older patients; however, close monitoring for potential toxicity is recommended.

Keywords: older patients, targeted therapy, solid tumors