Neurológia pre prax 4/2022

The influence of aging on course multiple sclerosis on climacteric and menopausal women

Multiple sclerosis is a chronic inflammatory disease of the central nervous system leading to demyelination and neurodegeneration. The disease is clearly more common in women. Being a women is one of the strongest risk factors for multiple sclerosis. Menopause is one of the evolutionary stages that all women experience trough aging and this fenomenon exposes them to massive changes. Boath healthy and RS women could have some healthy problems. In clinical practice, symptoms of MS and menopause can frequently overlap. The presence of MS does not appear to influence age of menopausal onset, but MS disability during and after menopause seems to worsen. Mechanisms through which menopausal MS women experience disability progression include neuroinflammation and neurodegeneraration from age associated phenomena. Menopause – related declines in sex hormone levels may contribute to a reproductive senescence. An immportant factor to age-related MS disability progression is immunosenescence. Premature ovarian failure is defined as hypergonadotropic amenorrhoea, has a diverse etiology and autoimunity may play a role.

Keywords: multiple sclerosis, menopause, disability, reproductive senescence, premature ovarian failure