Neurológia pre prax 5/2017

T- lymphocytes and B-lymphocytes ant their role in multiple sclerosis

The multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of central nervous system. The inflammatory processes are present especially in early stages of MS. The neurodegenerative processes play role especially in later stages. There are characteristic inflammatory infiltrations (particularly in white matter) in MS. In these lesions are activating cells, ie. T-lymphocytes, macrophages and B- lymphocytes. Autoaggressive T and B lymphocytes have various functions in patogenesis of MS and play any role in the demyelination of nerve fibers and damage of axons. The knowledge of their function is important for understanding the MS and for development of the drugs modifying disease. In addition to autoimmune processes, the environmental factors (geographical, lifestyle, infections) have an important role in MS patogenesis.

Keywords: multiple sclerosis, T lymphocytes, B lymphocytes, autoimmune processes