Neurológia pre prax 1/2025
Study of gut microbiota in the context of neurological disorders
The gut microbiota has recently come to the forefront of scientific interest, particularly due to its broad spectrum of action not only on tissues that it comes into direct contact with, but also – through a variety of agents – on distant tissues and organs. There are a number of previously described mechanisms through which gut-colonizing microorganisms can affect the host’s immune or endocrine systems as well as the central nervous system and behaviour of the host. A number of research teams are studying the microbiome in relation to neurological diseases, investigating the possible effect of specific microorganisms and microbial metabolites on the development and progression of these diseases. This publication deals with those diseases that have been most widely studied and described in this context.
Keywords: microbiome-gut-brain axis, neuropeptides, short-chain fatty acids, autism spectrum disorder, Parkinson’s disease, Alzheimer’s disease, multiple sclerosis
