Neurológia pre prax 6/2010

Multiple sclerosis and inherited thrombophilia

Multiple sclerosis (MS) is a heterogenous disease of central nervous system (CNS) with variable clinical signs. The onset of MS may imitate the whole scale of different, not only neurological diseases and detailed differential diagnosis of it is recommended. The goal of our study was to alert the possible coincidence of MS and inherited thrombophilia, the difficulties in diagnosis of clinically isolated syndrome suspected from MS in patients with inherited thrombophília and analyse its possible complications in patients with clinically definitive MS. Out of 412 MS patients from both MS centres in Košice and in Prešov we have found in retrospective analyses 24 ones with this deficiency of haemosthasis. Due to our information, this topic was not researched in Slovak MS population so far.

Keywords: multiple sclerosis, clinically isolated syndrome, inherited thrombophilia.