Neurológia pre prax 2/2010

Primary brain lymphoma

Primary central nervous system lymphoma (PCNSL) makes 1–2 % of all primary cerebral tumors. In contrast to lymphomas arising from nodal lymphatic tissues, PCNSL affect cerebral tissue. These tumors belong to a variety of non-Hodgkin lymphomas. Their occurrence is especially in immunocompromised patients. PCNSL is in principle good curable with chemotherapy and radiotherapy. The tumor sometimes does not show on follow-up imaging examination after intensive immunosuppressive therapy. Therefore, this tumor is also marked as a vanishing tumor. The diagnosis of PCNSL is verified by the immunohistochemical examinations which certify lymphoid tumor cells. If there are doubts between histological and imaging examination, problems will appear. These problems complicate the course of this disease. We treated a patient with this complicated course of disease in our clinic.

Keywords: primary central nervous system lymphoma, non-Hodgkin lymphoma, corticotherapy, brain biopsy, chemotherapy, radiotherapy.