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Neurológia pre prax 1/2015
Patophysiology of motor adverse event of long term treatment of Parkinson’s disease with dopaminergic medication
Treatment of Parkinson’s disease with dopaminergic preparation has besides the positive effects on the course of the disease many side effects. The most prominent adverse event of long term administration of levodopa and dopamine receptor agonist are motor fluctuation, levodopa induced dyskinesias and psychotic side effects. Authors in the article describe the patophysiology of motor fluctuation and levodopa induced dyskinesias in the patients with Parkinson’s disease treated by dopaminergic medication.
Keywords: dyskinesias, motor fluctuation, priming, pulsative stimulation dopamine denervation, pharmacokinetics of levodopa.
