Neurológia pre prax 4/2011

New guidelines for diagnosis and therapy of Alzheimer´s disease

Guidelines for diagnosis and therapy of Alzheimer´s disease provides an evidence based review of the literature. Scientific papers are assessed according to levels of evidence, where I means the most convincing and IV means the weakest evidence. There was provided a recommendation of level A – efficient, B – probably efficient and C – possibly efficient, based on the levels of evidence. Presented guidelines revise previous recommendations published in 2007. New biomarkers of Alzheimer´s disease are discussed, especially examination of cerebrospinal fluid, magnetic resonance and other imaging methods, as well as new neuropsychological instruments. In the pharmacological section, there are critically evaluated many substances lacking sufficient evidence of its efficacy, but still used in the Czech Republic.

Keywords: guidelines, evidence based medicine, Alzheimer´s disease, diagnosis, management.