Neurológia pre prax 1/2023

Molecular and cellular biology of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a severe progressive disease characterized by changes in upper and lower motor neurons. Due to degeneration and extinction of motoneurons, muscle weakness and atrophy gradually occur. ALS is increasingly considered a multisystem disease. Understanding the pathogenesis of ALS is important for the development of effective therapeutic approaches. The aim of this article is to identify and summarize selected molecular and cellular mechanisms involved in the pathogenesis of ALS - mitochondrial dysfunction, aberrant RNA metabolism, oxidative stress, as well as molecular approaches to treatment.

Keywords: amyotrophic lateral sclerosis, motoneuron disease, mitochondrial dysfunction, aberrant RNA metabolism, molecular approaches to treatment