Neurológia pre prax 3/2023

Laboratory biomarkers – neural antibodies in autoimmune diseases of the central nervous system

neural antigens, with a separate category of glial antigens. Diagnostic possibilities are broad, interpretation of the results is, however, not always simple. As there is a possibility of false positive and negative results, the recommendation is to use two different methods of detection and examine both serum and cerebrospinal fluid samples. Diagnosis should always be based on a synthesis of clinical and laboratory findings. In case of inconclusive results (negative antibodies in a clear clinical suspicion or positive antibodies with atypical clinical findings), reference laboratory should be consulted.

Keywords: autoimmune encephalitis, neural antibodies, cell‑based assay, tissue‑based assay, line blot