Dermatológia pre prax 1/2016

Impact of life style change to biochemical parameters in psoriasis patients

Purpose: The aim of study was to elicit the impact of dietary and life style change to psoriasis and associated diseases. Patients and methods: 50 obese patients with moderate to severe psoriasis were included into study. Patients were divided into two groups – exercising group with dietary and life style change and a group of non-exercisings without life style change. The laboratory parameters, BMI, weight, quality of life, PASI were monitored during 48 weeks. Patients were treated with systemic treatment. In control group were included 32 obese persons without psoriasis. Results: It was observed decreases of PASI, weight and BMI in both groups. The mean cholesterol level was elevated in both groups. HDL cholesterol level was lower in non-exercising patients. Mean LDL level was without significant difference between exercisings and non-exercisings. Mean sdLDL level was incerased in non-exercising patients only. Mean triglycerides level was increased in all patients but in exercisings with decreasing trend whereas in non-exercisings was observed increasing trend. Mean adiponectin, leptin, glutathione, coenzyme Q10 levels were mostly in normal range. TNFα level was increased in non-exercising patients with increasing trend; in exercisings was markedly lower. IL-12 level was incresing in both patient´s groups, whereas significantly in non-exercisings. IL-23 level was increasing in non-exercising patients. Conclusion: In patients with dietary change and regular physical activity HDL and adiponectin levels have increased. sdLDL cholesterol and triglycerides levels have decreased. Proinflammatory cytokines levels (TNFα, IL-12, IL-23) were globally lower in exercising in comparision with group without life style change and without physical activity.

Keywords: psoriasis, obesity, biochemical parameters, cytokines, comorbidities