Dermatológia pre prax 2/2017

Subacute cutaneous lupus erythematodes in a patient with SHARP syndrome – case report

Purpose: Subacute cutaneous lupus is typically associated with annular erythematous plaques on the skin. The “christmas tree” pattern of skin lesions is characterized. Subacute lupus can by induced by numerous drugs, such as calcium channel blockers, angiotensin-converting enzyme inhibitors, statins, terbinafine, including proton pump inhibitors. Case report: Authors refer a case of a patient with SHARP syndroma, who developed anular skin lesions two months after being treated by omeprazole due to gastric problems. Conclusion: Omeprazole is the proton pump inhibitor used for blocking of gastric acid. It is very often prescribed as an adjuvant therapy during corticosteroid medication. Various side effects of omeprazole are referred, but lupus-like reactions are very rare.

Keywords: subacute cutaneous lupus erythematosus, drug induced lupus erythematosus, proton pump inhibitors (PPI), omeprazole, SHARP syndrome, mixed connective tissue disease, overlap connective tissue disease